Notter M, Thomsen AR, Nitsche M, Hermann RM, Wolff H, Habl G, Münch K, Grosu AL, Vaupel P published in cancers 2020, 12, 606 the evaluation of 201 patients with inoperable, locally recurrent breast cancer (LRBC) in a pre-irradiated area. Patients were treated from 2009 - 2019 in Hôpitale Cantonale La-Chaux-de-Fonds, Lindenhofspital Bern, University Medical Center Freiburg, Center of Radiotherapy and Radiooncology Bremen, and Radiology Munich (Strahlentherapie am Maximiliansplatz).

Thermography controlled wIRA superficial hyperthermia (45-60 minutes) was performed 1-4 minutes before hypofractionated radiotherapy of 5 treatments at 4 Gy, 1x/week.

Since the size of tumor is one of the most important prognostic factors, a novel size classification was used for evaluation:

Tumor response rates (CR=Complete Response, PR=Partial Response, NC=No Change, PD=Progressed Disease) were:

  • rClass I (Ø ≤10cm): CR 76%, PR 24%
  • rClass II (> 100 cm², ipsilateral): CR 61%, PR 36%, NC 3%
  • rClass III (contralateral): CR 36%, PR 61%, PD 2%
  • rClass IV (extension on the back, „cancer cuirasse“): CR 2%, PR 83%, NC 10%, PD 5%

Local control rate during lifetime was 67% in patients with CR, local progression-free rate during lifetime was 55% in patients with PR.

While compared to other clinical studies on HT/RT in LRBC, pre-irradiation dosage as well as the size of tumour lesions were highly above-average, the total re-irradiation dosage of 5 x 4 Gy = 20 Gy was the lowest dosage ever reported.

Side-effects were limited to acute toxicity of grade I and II, and only in few patients chronic side-effects of teleangiectasia and hyperpigmentation.

The low toxicity even allowed for the effective re-reirradiation of re-recurrences in the same region using the same protocol.

The publication including detailed analysis of patient characteristics, local control, survival and location as well as re-re-irradiation of re-recurrences, is fully available OPEN ACCESS https://www.mdpi.com/2072-6694/12/3/606

 

 

 

 

 

 

Print Email


heckel medizintechnik GmbH

Olgastrasse 25
73728 Esslingen

Tel: ++49 (0)711 - 128989 - 0

info@heckel-medizintechnik.de

 

Visit us on Facebook
 

Visit us on Linkedin

 

PARTNER OF

hydrosun

>

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.