Table of Content:

SELECTED LITERATURE

RUNNING CLINICAL TRIALS USING HECKEL SYSTEMS


 



 

Depression

1. Clinical studies using heckel WBH systems

Janssen CW, Lowry CA, Mehl MR, Allen JJ, Kelly KL, Gartner DE, Medrano A, Begay TK, Rentscher K, White JJ, Fridman A, Roberts LJ, Robbins ML, Hanusch KU, Cole SP, Raison CL:
Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder: A Randomized Clinical Trial    
JAMA Psychiatry. 2016 Aug 1;73(8):789-95
OPEN ACCESS: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2521478
 

Raison CL, Janssen CW, Lowry CA:
Hyperthermia for Major Depressive Disorder?-Reply.
JAMA Psychiatry. 2016 Oct 1;73(10):1096-1097
https://www.ncbi.nlm.nih.gov/pubmed/27627698
 

Hanusch KU, Janssen CH, Billheimer D, Jenkins I, Spurgeon E, Lowry CA, Raison CL
Whole-Body Hyperthermia for the Treatment of Major Depression: Associations With Thermoregulatory Cooling
Am J Psychiatry 170:7, July 2013
https://www.ncbi.nlm.nih.gov/pubmed/23820835


2. Clinical studies using other WBH techniques

Naumann J, Grebe J, Kaifel S, Weinert T, Sadaghiani C, Huber R
Effects of hyperthermic baths on depression, sleep and heart rate variability in patients with depressive disorder: a randomized clinical pilot trial
BMC Complement Altern Med. 2017; 17: 172
OPEN ACCESS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371197/


3. Reviews, overviews, book chapters

Hanusch KU, Janssen CH
Die Ganzkörperhyperthermie in der Psychiatrie - Eine historische Analyse
[ARTICLE IN GERMAN] Die Naturheilkunde 02/2013
 

Hanusch KU:
“Antidepressive” Effect through Heat Therapy - Influence of the psychical condition of depressive patients through passive whole-body hyperthermia.
MASTER'S THESIS, Clinical Psychoneuroimmunology, University of Girona (UdG) / University of Graz, Uni4Life, Nov. 2012
https://www.researchgate.net/profile/Kay_U_Hanusch/publication/255685750_Antidepressive_Effect_through_Heat_Therapy/links/00b7d520286fe9f1c8000000/Antidepressive-Effect-through-Heat-Therapy.pdf
 

Janssen C, Hanusch KU
Passive Ganzkörperhyperthermie bei Depressionen
[ARTICLE IN GERMAN] Die Naturheilkunde 05/2011

 




 

Fibromyalgia

1. Clinical studies using heckel WBH systems

Romeyke T, Stummer H
Multi-Modal Pain Therapy of Fibromyalgia Syndrome with Integration of Systemic Whole-Body Hyperthermia – Effects on Pain Intensity and Mental State: A Non-Randomised Controlled Study
Journal of Musculoskeletal Pain Vol: 22, Issue 4, December 2014, pages 341-355
http://www.tandfonline.com/doi/full/10.3109/10582452.2014.949336


Romeyke T, Scheuer HC, Stummer H
Fibromyalgia with severe forms of progression in a multidisciplinary therapy setting with emphasis on hyperthermia therapy--a prospective controlled study    
Clin Interv Aging. 2014 Dec
OPEN ACCESS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279606/

 

2. Clinical studies using other WBH systems

Brockow T, Wagner A, Franke A, Offenbächer M, Resch KL
A randomized controlled trial on the effectiveness of mild water-filtered near infrared whole-body hyperthermia as an adjunct to a standard multimodal rehabilitation in the treatment of fibromyalgia.
Clin J Pain. 2007 Jan;23(1):67-75
https://www.ncbi.nlm.nih.gov/pubmed/17277647
 

3. Clinical case reports using heckel WBH systems

Winnicki C, Hanusch KU
Hyperthermie gegen Fibromyalgiesyndrom
Schweiz Z Ganzheitsmed 2013;25:267-268
[ARTICLE IN GERMAN] OPEN ACCESS https://www.karger.com/Article/FullText/355025
 

4. Others

Häuser W, Jung E, Erbslöh-Möller B,Gesmann M, Kühn-Becker H,Petermann F, Langhorst J, Thoma R, Weiss T, Wolfe F, Winkelmann A
The German fibromyalgia consumer reports – a cross-sectional survey
BMC Musculoskelet Disord. 2012; 13: 74
OPEN ACCESS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444387/

 




 

Oncology (A) fever-range WBH

1. Clinical studies using heckel WBH systems

Kobayashi Y, Itoa Y, Ostapenko VV, Sakai M, Matsushita N, Imai K, Shimizu K, Aruga A,Tanigawa K
Fever-range whole-body heat treatment stimulates antigen-specificT-cell responses in humans
Immunology Letters 162 (2014) 256–261
https://www.ncbi.nlm.nih.gov/pubmed/25256774


Sulyok I, Fleischmann E, Stift A, Roth G, Lebherz-Eichinger D, Kasper D, Spittler A, Kimberger O.
Effect of preoperative fever-range whole-body hyperthermia on immunological markers in patients undergoing colorectal cancer surgery
Br J Anaesth. 2012 Nov;109(5):754-61
OPEN ACCESS https://academic.oup.com/bja/article/109/5/754/305182/Effect-of-preoperative-fever-range-whole-body


Bull JM, Scott GL, Strebel FR, Nagle VL, Oliver D, Redwine M, Rowe RW, Ahn CW, Koch SM.
Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-alpha: a description of a phase I-II protocol.
Int J Hyperthermia. 2008 Dec;24(8):649-62
https://www.ncbi.nlm.nih.gov/pubmed/18608594


Kraybill WG, Olenki T, Evans SS, Ostberg JR, O'Leary KA, Gibbs JF, Repasky EA.
A phase I study of fever-range whole body hyperthermia (FR-WBH) in patients with advanced solid tumours: correlation with mouse models.
Int J Hyperthermia. 2002 May-Jun;18(3):253-66
https://www.ncbi.nlm.nih.gov/pubmed/12028640


Congress abstracts:;

Kleef R:
Low-dose checkpoint inhibitor therapy with interleukin-2 (IL-2) and fever range hyperthermia in stage IV cancer: a retrospective analysis with single case presentations
ESHO 2017 21-23 June Athens, Greece, Abstracts OP-10
http://www.esho2017.eu/articlefiles/FINAL%20ABSTRACT%20BOOK%20VS2.pdf

 

2. Clinical case reports using heckel WBH systems

Rich LJ, Winslow TB, Alberico RA, Repasky EA, Seshadri M, Singh AK
Enhanced tumour perfusion following treatment with water-filtered IR-A radiation to the thorax in a patient with head and neck cancer.
Int J Hyperthermia. 2016 Aug;32(5):539-42, LETTER TO THE EDITOR
https://www.ncbi.nlm.nih.gov/pubmed/27150820
 

Kleef R, Moss RW, Szasz AM, Bohdjalian A, Bakacs T
Near complete remission of pulmonary metastases in triple negative breast cancer (TNBC) using low-dose immune checkpoint (IC) inhibitors with high dose (HD) interleukin-2 (IL-2) and fever range hyperthermia
EJC, Vol55, Suppl.1, March 2016; 3rd Immunotherapy of Cancer Conference 21–23 March, 2016, Munich/Germany
http://meetinglibrary.asco.org/record/127689/abstract
 

Kleef R, Kekic S, Ludwig N
Successful Treatment of Advanced Ovarian Cancer with Thermochemotherapy and Adjuvant Immune Therapy
Case Rep Oncol 2012;5:212–215
OPEN ACCESS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369243/

 

3. Pre-clinical studies

Rowe RW, Strebel FR, Proett JM, Deng W, Chan D, He G, Siddik ZH, Bull JMC
Fever-Range Whole-body Thermotherapy Combined With Oxaliplatin: A Curative Regimen in a Preclinical Breast Cancer Model
Int J Hyperthermia. 2010; 26(6): 565–576
OPEN ACCESS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045248/

 

4. Reviews

Yagawa Y, Tanigawa K, Kobayashi Y, Yamamoto M:
Cancer immunity and therapy using hyperthermia with immunotherapy, radiotherapy, chemotherapy, and surgery.
J Cancer Metastasis Treat 2017;3:218-30
OPEN ACCESS: http://jcmtjournal.com/article/view/2272
 

Repasky EA, Evans SS, Dewhirst M:
Temperature Matters! And Why it Should Matter to Tumor Immunologists.
Cancer Immunol Res. 2013 Oct 1; 1(4)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904378/


Faghihi Moghadam F, Bakhshandeh M, Sahinbas H:
Hyperthermia: A Neoadjuvant Therapeutic Approach in Cancer Treatment
CANCERPRESS Vol. 3, No.1, March, 2017
http://www.thecancerpress.com/index.php/cp/article/viewFile/35/55

 

5. Books, book chapters

Tanigawa K, Ito Y, Kobayashi Y
Effects of Fever-Range Hyperthermia on T Cell-Mediated Immunity: Possible Combination of Hyperthermia and T Cell-Based Cancer Immunotherapy
in: S. Kokura et al. (eds.), Hyperthermic Oncology from Bench to Bedside, Springer Science+Business Media Singapore 2016
https://link.springer.com/chapter/10.1007/978-981-10-0719-4_31


Rowe-Horwege
Hyperthermia, Systemic
in Enceclopedia of Medical Devices and Instrumentation, Second Edition, 2006 John Wiley & Sons, Inc.
http://onlinelibrary.wiley.com/book/10.1002/0471732877/homepage/SampleContent.html

 

6. Congress abstracts:

Wey S:
14 years fever-range whole body hyperthermia in adjuvant recurrence prophylaxis of breast cancer.
ESHO 2018 Berlin, P 12
https://link.springer.com/content/pdf/10.1007%2Fs00066-018-1295-1.pdf , p. 495
 

Wey S:
Secondary and tertiary recurrence prevention with fever range whole-body hyperthermia in (metastatic) malignant melanoma.
ESHO 2018 Berlin, P 13
https://link.springer.com/content/pdf/10.1007%2Fs00066-018-1295-1.pdf , p. 496
 

Kleef R, Bojar H, Moss R, Stix A, Bohdjalian A, Bacher V, Nagy R, McKee D:
Exogenous and endogenous hyperthermia combining lowdose checkpoint inhibitors with interleukin-2 (IL-2) and fever range whole body and local regional hyperthermia in stage IV cancer.
ESHO 2018 Berlin, P 35
https://link.springer.com/content/pdf/10.1007%2Fs00066-018-1295-1.pdf , p. 504
 

Pinto J, Ferreira A, Ferreira C, Cruz A, Pinto M:
Fever-range whole body hyperthermia with concomitant capecitabine in third line therapy for BRCA mutated metastatic breast cancer.
ESHO 2018 Berlin, P 38
https://link.springer.com/content/pdf/10.1007%2Fs00066-018-1295-1.pdf , p. 506
 

Kleef R:
Low-dose checkpoint inhibitor therapy with interleukin-2 (IL-2) and fever range hyperthermia in stage IV cancer: a retrospective analysis with single case presentations
ESHO 2017 21-23 June Athens, Greece, Abstracts OP-10
ESHO2017 ABSTRACTBOOK , p. 65
 

Kleef R, Bohdjalian A, McKee D, Moss RW:
Complete response of stage IIIB esophageal cancer combining low-dose checkpoint inhibitors with interleukin-2 (IL-2) and fever range hyperthermia.
Journal for ImmunoTherapy of Cancer 2017, 5(Suppl 1):12 DOI 10.1186/s40425-017-0219-4
https://jitc.biomedcentral.com/track/pdf/10.1186/s40425-017-0219-4 , A39, p.15

 


 

Oncology (B) extreme WBH

1. Clinical studies using heckel WBH systems

Changlin Zhao , Congqi Dai, Xiaoyin Chen    
Whole body hyperthermia combined with intraperitoneal chemotherapy for the treatment of stage IV advanced gastric cancer
Int.J.Hyperthermia, December 2012; 28(8): 735-741
https://www.ncbi.nlm.nih.gov/pubmed/23113543


Douwes F, Bogovic J, Douwes O, Migeod F, Grote C    
Whole body hyperthermia in combination with platinum-containing drugs in patients with recurrent ovarian cancer
Int J Clin Oncol. 2004 Apr;9(2):85-91
https://www.ncbi.nlm.nih.gov/pubmed/15108039


Gaworek J, Mayer CT    
Systemische Ganzkörperhyperthermie in der Onkologie: Tödliche Hitze für Tumorzellen
[Systemic whole body hyperthermia in oncology: fatal heat for tumor cells].

Pflege Z. 2003 Jan;56(1):15-8
[ARTICLE IN GERMAN] http://www.daryan.de/admin/download/file_150.pdf


Reichel M, Scheeren TWL, Douwes O, Konrad RM    
Tiefe intravenöse Analgosedierung zur extremen Ganzkörperhyperthermie in Kombination mit Chemotherapie
[Deep intravenous analgosedation for extreme whole-body hyperthermia in combination with chemotherapy]

Forum Komplementäre Onkologie & Forum Immunologie, 3/2004, 4-8
[ARTICLE IN GERMAN] OPEN ACCESS http://www.rug.nl/research/portal/files/38850130/2004_Tiefe_intravenoese_Analgosedierung_zur_extremen_Ganzkoerperhyperthermie_in_Kombination_mit_Chemotherapie.pdf

 

 


 

 

Chronic inflammation / chronic infection

1. Clinical studies using heckel WBH systems

Douwes F:
Komplextherapie der chronischen Borreliose (Lyme Disease) - Ein neuer Therapieansatz: die Antibiotika augmentierte Thermoeradikation (AAT).
OM & Ernährung 2018 / Nr. 164 [Article in German]
https://www.omundernaehrung.com/ausgaben/nr-164.html

Douwes F:
The successful antibiotic augmented thermal eradication of chronic lyme disease.
ESHO 2018 Berlin, P 43
https://link.springer.com/content/pdf/10.1007%2Fs00066-018-1295-1.pdf


Zauner D, Quehenberger F, Hermann J, Dejaco C, Stradner M, Stojakovic T, Angerer H, Rinner B, Graninger WB
Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis:A pilot study
Int J Hyperthermia, 2014; 30(6): 393–401
https://www.ncbi.nlm.nih.gov/pubmed/25256892


Fuchs, Y
Effekte einer moderaten Infrarot- Ganzkörper- Hyperthermie auf die Akut- Phase Reaktion
Diplomarbeit Medical University of Graz; 2010. pp. 73
[ARTICLE IN GERMAN] OPEN ACCESS: https://online.medunigraz.at/mug_online/wbabs.getDocument?pThesisNr=18419&pAutorNr=59958&pOrgNR=1


Hanusch KU, Janssen CH, Gluch A
Passive Infrarot-A-Ganzkörperhyperthermie (Heckelbett) bei rheumatischen Erkrankungen
Schweiz Z Ganzheitsmed 2011;23:327–330
[ARTICLE IN GERMAN] OPEN ACCESS https://www.karger.com/Article/PDF/334700

 

2. pre-clinical studies

Lee CT, Kokolus KM, Leigh ND, Capitano M, Hylander BL, Repasky EA.
Defining immunological impact and therapeutic benefit of mild heating in a murine model of arthritis.
PLoS One. 2015 Mar 20;10(3):e0120327
OPEN ACCESS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368208/


Reisinger E, Wendelin I, Gasser R, Halwachs G, Wilders-Truschnig M, Krejs G
Antibiotics and Increased Temperature against Borrelia burgdorferi in Vitro
Scandinavian Journal of Infectious Diseases, Vol.28, 1996, Issue 2, pp. 155-157
http://www.tandfonline.com/doi/abs/10.3109/00365549609049067

 

 

 




 

Others, general review and overview articles

Evans SS, Repasky EA, Fischer DT:
Fever and the thermal regulation of immunity: the immune system feels the heat.
Nat Rev Immunol. 2015 Jun; 15(6)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786079/


Kleef R
Hyperthermie und Entgiftung
OM & Ernährung 2011 / Nr.135
[ARTICLE IN GERMAN] http://www.omundernaehrung.com/ausgaben/nr-135.html


Heckel M, Dickreiter B
Ganzkörperhyperthermie – Kontrollierte Erhöhung der Körpertemperatur zu therapeutischen Zwecken
Natur-Heilkunde Journal, 10+11/2007

 




 

RUNNING CLINICAL TRIALS USING HECKEL SYSTEMS

Charite University Berlin, Department of Psychiatry and Psychotherapy
A randomized, double-blind controlled study of the efficacy of infrared-whole body hyperthermia in patients with major depression
https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00015754


Charite University Berlin, Department of Radiooncology:
Moderate Whole Body Hyperthermia for Patients Undergoing Re-irradiation for Head and Neck Cancer -Influence on the Tumor Microenvironment (GKH-TMM)
https://clinicaltrials.gov/ct2/show/NCT03547388?cond=Hyperthermia&cntry=DE&draw=2&rank=21
 

Roswell Park Cancer Institute Buffalo:
Body Warming in Improving Blood Flow and Oxygen Delivery to Tumors in Patients With Cancer
https://clinicaltrials.gov/ct2/show/NCT01896778?term=%22Buffalo%22+AND+%22Singh%22&rank=8


Based on these pre-clinical findings:

Sen A, Capitano ML, Spernyak JA, Schueckler JT, Thomas S, Singh AK, Evans SS, Hylander BL, Repasky EA
Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models.
Cancer Res. 2011 Jun 1;71(11):3872-80
OPEN ACCESS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184616/


Winslow TB, Eranki A, Ullas S, Singh AK, Repasky EA, Sen A:
A pilot study of the effects of mild systemic heating on human head and neck tumour xenografts: Analysis of tumour perfusion, interstitial fluid pressure, hypoxia and efficacy of radiation therapy
Int J Hyperthermia. 2015 Sep; 31(6): 693–701
OPEN ACCESS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573247/
 

First report on the running study:

Rich LJ, Winslow TB, Alberico RA, Repasky EA, Seshadri M, Singh AK
Enhanced tumour perfusion following treatment with water-filtered IR-A radiation to the thorax in a patient with head and neck cancer.
Int J Hyperthermia. 2016 Aug;32(5):539-42, LETTER TO THE EDITOR
https://www.ncbi.nlm.nih.gov/pubmed/27150820

 

 

 


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